Tw ok inases and the key fructose-6-phosphate aldolase (FSA) were involved in ao ne-pot multienzymatic procedure to obtain rare l-sugars. Starting from simplea chiral substrates such as glycolaldehyde andf ormaldehyde, l-glyceraldehyde-3phosphate( l -G3P) was generated. When this latter compound was used as an FSA acceptor substrate along with four different donor compounds,f our terminally phosphorylated l-monosaccharides from C 5 to C 7 chain lengths were preparedi ng oodi solated yields.

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