Background: Polycystic ovary syndrome (PCOS) is a multisystem metabolic disorder, which has a significant impact on the quality of life as well as fertility. 1,2 Acne, hirsutism, androgenetic alopecia, acanthosis nigricans, seborrhea are commonly associated with cutaneous manifestations of PCOS. To identify cutaneous manifestations, their incidence and frequency in patients with PCOS in different age groups. Methods: An institutional based prospective study. Seventy PCOS patients attending out-patient departments of DVL and Obstetrics and Gynaecology, NRI Medical College and General Hospital, Guntur, fulfilling the inclusion criteria were included in the study and examined for the presence of cutaneous manifestations in the two year study period between January 2017 and December 2018. Results: In the present study, 70 patients with PCOS were taken up and the commonest age group affected was 21-25 years (42.8%). Positive family history of PCOS was observed in 12.8%. The commonest cutaneous manifestation was acne vulgaris (57.14 %). Obesity was present in 47.14% of the patients and all of them were found to have striae. Hirsutism was observed in 47.14% of the total patients studied and the majority of them had terminal hair in the chin region and upper lip. Acanthosis nigricans was present in 34.28%, seborrhoea in 21.42% and acrochordons in 17.14% of the patients. Of the 70 patients, 15.7% were overweight and 47.14% were obesity. Conclusions: The cutaneous manifestations of PCOS reserves major role in its management by Dermatologist. Recognizing PCOS in women presenting with hyperandrogenism offers a significant opportunity to begin a life-long conversation about prevention and treatment of a condition that has a multi-system impact on affected women.

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DISCUSSIONNevus lipomatosus superficialis is a rare skin malformation characterized by the presence of ectopic mature adipose tissue in the dermis. 1,2 The proportion of the fatty tissue varies from 10-50% of the dermis. 3 Clinically, it is classified into the classical Hoffmann- ABSTRACTNevus lipomatosus cutaneous superficialis is a rare benign local malformation of the skin characterized by ectopic adipocytes in the dermis. It presents as either a classical type known as Hoffman-Zurhelle or the solitary type. We report a case of the classical type with multiple soft, non-tender, cerebriform, skin-colored papules and nodules over the lower back in a 16 years old female.

INTRODUCTIONAdverse drug reactions (ADRs) are unexpected or dangerous reaction to a drug and are a major clinical problem in terms of human suffering. Adverse cutaneous drug reactions (ACDRs) are the most common ADRs (30-45%) and are responsible for about 2% of hospital admissions. 1 ACDR occur with variable severity. A few can result in significant morbidity, health care costs, hospitalization, and death. The mortality rate in toxic epidermal necrolysis (TEN) can be high. 2The incidence of ACDRs among in-patients in developed countries and in developing countries such as India is 1-3% and 2-5% respectively. 1,3 Incidence among outpatients is 2-6%. 2 ACDRs are responsible for approximately 3% of all disabling injuries during hospitalization. The incidence of acute cutaneous drug reactions among all drug reactions is between 24-29%. The Incidence of drug eruptions in our country varies between 6 to 30 % and about 8% hospital admissions are due to drug eruptions. 4 The large majority of cases were in the age group of 21-40 years with female preponderance. 1 ABSTRACT Background: Adverse cutaneous drug reactions (ACDR) are the most frequent ADRs (30-45%) and are responsible for about 2% of hospital admissions and few can result in significant morbidity, health care costs, hospitalization, and death. To study different clinical patterns of ACDR, assess the cause and identify the offending drug and to study the relationship of ACDRs to age and sex among patients referred to the department of DVL, NRI General Hospital. Methods: This is a retrospective study of 70 cases of colorectal carcinoma analysing incidence, clinicopathological features and outcome after different therapies including surgery, radiotherapy and chemotherapy. It was a descriptive hospital-based case series study. All out-patients and in-patients referred to the department of DVL, NRIGH, Chinakakani and in whom a diagnosis of ACDR is made, form the subjects for this study. The study was conducted over a period of two years. Results: 100 patients with adverse cutaneous drug reactions were included in the study. 42 (42%) were males and 58 (58%) were females. The age group ranged from 6 to 80 years with a maximum (43) belonging to 21 to 40 years. Maculopapular rash was most common followed by urticarial drug reaction, FDE, acneiform eruptions, EMF, erythroderma, DRESS, SJS, SJS/TEN, TEN and drug-induced hyperpigmentation. NSAIDs were the commonest culprits followed by antibiotics, antiepileptics and ATT. Conclusions: The commonest ACDR was maculopapular rash followed by urticaria, FDE and acneiform eruption. Antimicrobials as a group were the most common offending agents followed by individual drugs like diclofenac (13%), isoniazid (11%), efavirenz (9) and prednisolone (8%).