At the higher education level, autonomous learning is one of the most important challenges facing education today, especially with the current situation caused by the pandemic, where students must acquire good academic habits, work in a self-regulated manner and with their own criteria to support decision making. This paper describes the research conducted in a Technological University where the inverted classroom model was implemented in a subject to analyze the impact of the implementation of this model in the autonomous learning of students. The methodology used was based on a mixed type study, initially with an exploratory scope for the qualitative part and an experimental design for the quantitative part. The main contribution of this research is the Flipped Classroom Framework for its implementation for both teachers and students. As far as the specific objectives are concerned, the first is to define the framework to facilitate the teaching-learning process using the flipped classroom model in the context of the Technological Universities model, the second is to know the advantages and disadvantages that the flipped classroom offers to the students and the third to propitiate the autonomous learning of the students of the subject of Multiplatform Mobile Development.