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Introduction: Methicillin resistant Staphylococcus aureus (MRSA) & Methicillin resistant Coagulase Negative Staphylococci(MRCoNS) are recognized as one of the most common organisms causing nosocomial and community-acquired infections and are multiple drug resistant. Clindamycin is one of the preferred agents to treat infections because of these bacteria. But they may develop resistance to clindamycin during therapy called as inducible clindamycin resistance leading to treatment failure. The present study aims at knowing the incidence of inducible clindamycin resistance in clinical isolates of staphylococci and their antibiogram.Materials and Methods: The detection of inducible clindamycin resistance was performed by D-test using erythromycin and clindamycin discs as per CLSI guidelines. Standard disc diffusion test was performed to know the antibiogram for staphylococci.Results: The incidence of MRSA in the present study was 21.46 % and for MRCoNS was 39.94 % .The incidence of inducible clindamycin resistance for MRSA and MRCoNS was 65% and 17.30% respectively. For staphylococci the best sensitivity result was for linezolid.Conclusion: In the present study the incidence of methicillin resistance in Staphylococci was high. Therefore performing the D test is must for identifying true clindamycin resistance to bring out beneficial treatment out comes in the patients.