Objective: To explore the related factors of atherosclerosis in senile obstructive sleep apnea hypopnea syndrome (OSAHS) patients. Methods: 129 outpatients and inpatients with senile hypertension and type 2 diabetes were chosen from Department of Geriatrics during May of 2012 to January of 2014. The sleep breath monitoring was performed to each patient in the early stage. According to the presence or absence of OSAHS, they were divided into OSAHS (n = 60) and non-OSAHS (n = 69) groups. And 30 healthy elderly subjects recruited in Physical Examination Department of our hospital were included in the control group. The parameters of age, gender, height, body mass index, hypersensitive C-reactive protein (Hs-CRP), homocysteine (Hcy), triglyceride (TG), total cholesterol (TC), high density lipoprotein-cholesterol (HDL-C), low density lipoprotein-cholesterol (LDL-C) and carotid intima-media thickness (CIMT) were recorded. The comparison of Hs-CRP, Hcy, TG, TC, HDL-C, LDL-C and CIMT between OSAHS and non-OSAHS groups was made; and the comparison with the normal control group was made to analyze the correlations of CIMT to the above-mentioned indexes. (OSAHS group vs. control group, t = 5.88, 18.15, 15.62, 5.91, 9.17, 7.47; t = 2.20, 10.73, 11.51, 4.09, 8.56, 4.45; t = 4.84, 11.72, 5.54,3.91, all p < .05). Related analyses showed that CIMT and plaque score in OSAHS group were correlated to age, BMI, TG, TC, LDL-C, Hs-CRP and Hcy respectively. Conclusions: OSAHS may elevate the level of inflammatory cytokines and cause atherosclerosis. And the changes of CIMT, Hs-CRP and Hcy are in parallel. Hcy also has an identically important clinical significance in the progress of atherosclerosis.
A case of "Hypopituitarism and pituitary apoplex induced by pituitary Adenomas" was collected in the Third Affiliated Hospital of Inner Mongolia medical University Geriatric Department. A rare and atypical disease as it is, delayed diagnosis and treatment is easily seen among those cases. Therefore, the paper aims to investigate the difference of clinical characteristics and treatment outcome of pituitary adenomas in elder patient through the case analysis. Clinically, patients with pituitary dysfunction may have life-threatening crisis so that timely diagnosis and aggressive treatment can be effective in reducing the pituitary crisis and reducing the misdiagnosis rate. Key Words: Pituitary tumor, Pituitary dysfunction, Pituitary apoplexy1 Medical record General informationA 75-year-old man who complained of intermittent weakness, dizziness, nausea, vomiting of 2 month's duration was admitted to our hospital on November 13, 2010. He had intermittent weakness, dizziness, transient amaurosis during body position changes 2 months prior his admission. Blood pressure was repeatedly measured to be low, 80-90/50-55 mmHg. He felt morning nausea, vomiting, loss of appetite. However, no headache, rash, epistaxis and gum bleeding, no cough and chest tightness, shortness of breath, abdominal pain, diarrhea, no vomiting, bloody diarrhea, joint pain or activity limitation, urine abnormal was manifested. The laboratory test results at the outpatient service included: blood K + 4.3 mmol/L, Na + 127 mmol/L, Cl − 90 mmol/L. Specific past medical history and family medical history were denied. Physical examinationData on the physical examination revealed his temperature 36.8°C, Blood pressure 85/55 mmHg. He was poor spirited with pale appearance, smooth breathing, and dry skin, systemic superficial lymph node was not swollen and no rash was discovered. He had sparse pubic and armpit hair. Palm and gum pigmentation were not obvious. Left lung breath sounds resonance, while the other side sound decreased. The heart rate was 63 times per minute, showing regularity in the heartbeat. His abdomen was soft. No enlargement of liver, spleen and kidneys beneath the rib was found. No edema was seen in lower extremity, or redness, swelling, heat, pain, limited mobility was accompanied. Besides that, nervous system was normal.
A case of Sheehan's syndrome and anterior hypopituitarism was collected in Geriatric department of the third clinical college of Inner Mongolia medical university. Due to atypical clinical symptoms, it is easy to be delayed in its diagnosis and treatment. The paper aims to investigate the difference of clinical characteristics and treatment outcome of anterior hypopituitarism through case analysis.
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