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Aim: This investigation was organized to assess the antibacterial action and fluoride release capacity of Alkasite material (Cention N) in compare with two bioactive materials (Activa BioACTIVE restorative and Zirconomer) at different time intervals Materials and methods: Total 75 disc formed specimens of 3 various restorative materials (Zirconomer, Activa BioACTIVE, and Cention N) were prepared. 45 specimens for fluoride release (n =15) and 30 specimens for antibacterial activity (n=10). For fluoride release the specimens divided into 3 groups (n =15) Group1: Zirconomer, Group2: Cention N and Group 3: Activea bioactive. Each fluoride release group was further subdivided into three equal subgroups (n=5) according to the storage time (one day, 7days and 14days). For Antibacterial activity specimens divided into 3 groups (n=10) Group1: Zirconomer, Group2: Cention N and Group 3: Activea bioactive. Fluoride release was estimated at the finale of Day 1, 7and Day 14, using fluoride ion-selective electrode. Also, Antibacterial Activity and diameters of inhibition zone were recorded after 48 hours. Data analysis was performed using ANOVA and post-hoctest.Results: Zirconomer group revealed significantly the highest mean fluoride release value than in Cention N and Activea bioactive. Also, Cention N significantly higher fluoride release than Activa BioACTIVE. Cention N group showed statistically significant largest inhibition zone anti Streptococcus mutans at 48 hours followed by Zirconomer group, the smallest inhibition zone was observed with Activa bioactive group. Conclusion:Cention N and Zirconomer had better antibacterial activity and fluoride release while Activea bioactive had limited antibacterial activity and fluoride release.