The aim in this study was to investigate if the use of dexpanthenol could play a role in the relief of pain in the treatment of corneal abrasions (CA). Materials and methods: Patients presenting to the ophthalmology department and had a diagnosis of CA were conducted in this retrospective, case-control study. A detailed ocular examination was done and pain severity was assessed using a visual analogue scale (VAS) score. In group 1, subjects were treated with only topical ofloxacin 0.3% while subjects in group 2 were treated with topical ofloxacin 0.3% and dexpanthenol. Foreign body sensation, photophobia, excessive lacrimation and VAS were documented on the first, third and seventh days of follow up examinations. Results: 70 patients were allocated into group 1 and 68 patients were allocated into group 2. There were significant differences in VAS scores between the groups on the first, third and seventh days of follow up (p=0.002, p<0.001 and p<0.001, respectively). VAS scores were lower in group-2. There were no statistically significant differences between two groups in terms of photophobia, foreign body sensation, excessive lacrimation (p>0.05). All patients were free of any complications. Conclusion:Although it was shown that adding topical dexpanthenol to the treatment regimen could permit faster pain relief in treating CAs, the prospective studies should be done.