Objective. To analyze the effect of calisthenics on hypoglycemic in diabetic patients. Method. From September 2019 to May 2020, 210 patients with type 2 diabetes who were newly diagnosed in our hospital were chosen. They were split into two groups: observation ( n = 105 ) and control ( n = 105 ). Only drug therapy and diet management were given to the control group, whereas the observation group was given calisthenics treatment in addition to regular diet control and medicine. The outcomes of the two groups of patient’s blood glucose levels, BMI, quality of life, and blood lipid index were compared in this study. Results. Before treatment, there was no significant difference in FPG, 2hPG, and HbA1c levels between the two groups ( P > 0.05 ). Compared with before treatment, FPG, 2hPG, and HbA1c were significantly reduced in both groups ( P < 0.05 ). In addition, FPG, 2hPG, and HbA1c in the observation group were significantly lower than those in the control group ( P < 0.05 ). There was no significant difference in BMI between the two groups before treatment ( P > 0.05 ). After treatment, the BMI of the two groups was significantly reduced ( P < 0.05 ), and the BMI of the observation group was significantly lower than that of the control group ( P < 0.05 ). A comparison of the two groups’ SF-36 scale scores before intervention revealed no statistically significant difference ( P > 0.05 ). The observation group’s SF-36 scores were substantially higher than the control group’s after intervention ( P < 0.05 ). After treatment, the TC and HDL-c levels in the observation group were not significantly different from those in the control group ( P > 0.05 ). Compared with the control group, TG and LDL-C levels were significantly decreased, with statistically significant differences ( P < 0.05 ). Conclusion. Based on routine nursing intervention, using calisthenics to treat blood sugar has a significant effect, it not only made the patient’s self-care ability significantly improved, which was worthy of active promotion in clinical practice.