Magnetism of a complex [Fe(H2Bpz2)2(bipy-NH2)] (H2Bpz2 = dihydrobis(1-pyrazolyl)borate, bipy-NH2 = 4,4'-diamino-2,2'-bipyridine) has been altered from paramagnetic to spin-crossover (SCO) behavior, through protonation of one amino group of bipy-NH2 with CF3SO3H. Complete SCO transition, both in solid state and in solution, occurs at ambient temperature.

Cisplatin is a potent antitumor drug, which is widely applied in clinical cancer treatment. However, cisplatin can hardly distinguish between healthy tissue and tumor tissue, resulting in serious toxic side effects. Indocyanine green (ICG) is a FDA-approved near-infrared (NIR) fluorescence dye which has been used in photothermal therapy and optically mediated diagnostic, but the application of ICG is limited by its concentration-dependent aggregation, poor aqueous stability in vitro, lack of target specificity and rapid elimination from the body. Herein, to overcome these limitations of cisplatin and ICG, we fabricated folate-modified, cisplatin, ICG-loaded lipid-polymer hybrid nanoparticles (FCINPs) using a single-step sonication method. The FCINPs exhibited well-defined monodispersity, significant stability and excellent NIR penetration ability. The intracellular uptake experiment showed that the targeting efficacy of the FCINPs was more effective in folate receptors (FRs) over-expressing MCF-7 cells than FRs negative A549 cells. In addition, compared with chemo or photothermal treatment alone, the treatment of FCINPs in combination with 808 nm NIR laser irradiation can significantly induce the apoptosis and necrosis of MCF-7 cells. These findings indicated that the FCINPs would be a promising nanosized drug formulation for tumor-targeted therapy in the future.

The introduce of halogen atoms (F, Cl, Br, I) to the triazolebased ligand N-benzyl-4-amino-1, 2, 4-triazole (L) have shown a significant effect on the spin-crossover (SCO) properties of the corresponding one-dimensional (1D) coordination Fe (II) polymers with chemical formula [Fe(4-X-L) 3 ](BF 4 ) 2 (X = F, Cl, Br, and I). Compared with the [FeL 3 ](BF 4 ) 2 , the electronegative halogen atoms have increased the p-acceptor character of these ligands, which thus improved the ligand field strength and in-duced the occurrence of SCO for the Fe (II) polymers at higher temperatures. The SCO transition temperatures T 1/2 have changed from 200 K to 249 (I), 250 (Br), 252 (Cl) and 275 (F) K, respectively. More importantly, the UV-Vis absorption spectrum and density functional theory (DFT) calculations indicated that the transition temperatures and the width of thermal hysteresis loops have shown a positive correlation with the electronegativity of the halogen atoms.

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Despite a myriad of investigations have been performed both experimentally and theoretically, water remains not fully understood. Here, a new two‐dimensional (2D) supramolecular ice layer, which containing (H2O)6 hexagonal rings with “quasi‐chair” conformation, has been templated by an organic carboxylic host 1‐methyl‐4‐imidazole‐carboxylic acid. This unique infinite 2D ice layer, which is almost identical to ice Ih, packed into three‐dimensional architecture via hydrogen bonding contacts regulated by 1D chains of organic hosts, giving a slit‐width between adjacent layers of about 1.2 nm (12 Å).