Objective: Describe the compliance with Antibiotic Prophylaxis (AP) in selected surgical procedures in a community hospital during a 3.5 year period. Methods:Descriptive study was carried out in a 75-bed public hospital in Western Qatar. The study included the patients underwent selected procedures who required antibiotic prophylaxis from Jan-2013 to June 2016. Data was collected by the infection control practitioner, from patient files to assess the compliance with timing, selection and dose and discontinuation of the antibiotic prophylactic as per policy, with a 100% compliance set as a program goal. The local infection control program mandates the monitoring of AP, feedback and staff education.Results: Data on 2386 procedures was collected. The 46.5% of the procedures were performed by general surgery, with lower frequency for trauma (24.4%), Gyn-Obst (17.8%) and plastic surgeries (11.3%). The compliance with timing and selection and dose was 61.1% and 94.4% during the first quarter, after which was observed figures over 98%. The discontinuation had the lowest figures during the quarter 2 to 4, with increased compliance over 99% after the quarter seven. Conclusion:Even when the compliance with antibiotic prophylaxis did not achieve the goals, especially for the timely administration, an increased adherence with guidelines was observed during the study period as a result of the strategy implemented by the infection control program. KeywordsAntibiotic prophylaxis, Surgical procedures, Compliance, Qatar is related with prolonged hospital stay, increased cost and other adverse outcomes [1,2]. The preventable outcomes of inappropriate antimicrobial use include infectious morbidity, sepsis-related mortality, and the incidence of Clostridium difficile infections and the emergence of antimicrobial resistant organisms [3].The guidelines emphasize on three key issues: The timely administration before surgical procedures, the selection of the antibiotics according to the expected microbial flora in the surgical site, the re-dosing schedule in specific conditions and the duration of the prophylaxis [2]. Published reports describe a variable compliance with guidelines and the effectiveness of an intervention for its improvement [4][5][6][7][8][9].In public health hospitals in Qatar, the antibiotic prophylaxis is guided by a corporate policy and the compliance is monitored by the infection control department. The aim of this study was to describe the compliance with antibiotic prophylaxis in selected surgical procedures in a community hospital during a 3.5 year period.