Ingurumen-estimulu batek garuneko neurokimikan aldaketak eragin ditzake, koadro neuropsikiatrikoak eraginez. Ildo horretan, isolamendu sozialak eragindako bakardade-sentimenduek estres kronikoaren egoera eragin dezakete, eta horrek aldaketa neuroendokrinoak eta immunologikoak eragiten ditu. Aldaketa horiek serotonina gutxitzea eragin lezakete, depresioa eraginez. Artikulu honetan, gizarte-isolamenduak eragindako depresioaren neurobiologian izandako aurrerapenak deskribatzen dira.
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