: Development in the field of bio-inorganic chemistry increased the interest in Schiff base and it's complexes due to its biological importance in many fields, including anticancer activity. Discovery of the antitumor activity of Schiff base and it's complexes against various tumor cell lines, fascinates the researchers to develop new anticancer drugs without any side effects. Thus, the present review is focusing on the anticancer activity of Schiff bases and its metal complexes.

A comprehensive review, >100 references, on organotin(IV) complexes of the carboxylic acid derivatives are presented with special reference to their methods of synthesis, spectroscopic and structural studies and their biological activities. The structures of these complexes are discussed on the basis of IR, multinuclear (1H-, 13C- and 119Sn-) NMR.

A new series of diisopropyloxytin- and triorganotin(IV) complexes of H2hbgl (1) of the general formula Sn(OPri)2(hbgl) (2), Sn(OPri)2(Hhbgl)2 (3), Ph3Sn(Hhbgl) (4), Bu3Sn(Hhbgl) (5) and Me3Sn(Hhbgl) (6), [where H2hbgl= a ligand of thymol derivative namely, N-(2-hydroxy-3-isopropyl-6-methyl benzyl)Glycine] were synthesized by reacting tin- and triorganotin(IV) chloride with the ligand, with the aid of sodium iso-propoxide in appropriate stiochiometric ratios (1:1 and 1:2). These complexes were characterized by elemental analysis, IR, 1H nuclear magnetic resonance. The spectral data suggest that the carboxylate group, in complexes 2-5, was bonded in a bidentate manner, while a unidentate bonding was observed in complex 6. All five complexes were tested in vitro for their antibacterial activity against Gram-positive bacteria namely, Staphylococcus aureus MTCC 96, Bacillus subtilis MTCC 121 and two Gram-negative bacteria namely, Escherichia coli MTCC 1652 and Pseudomonas aeruginosa MTCC 741. All the five complexes were also tested against three pathogenic fungal strains namely, Aspergillus niger, A. flavus and Penicillium sp

A new series of tin(IV) complexes of general formula [Sn(L-1)(Opri)2] (1), [Sn(HL-1)2(Opri)2] (2), [Sn(L-2)(Opri)2] (3), [Sn(HL-2)2(Opri)2] (4), (L is dianion of Schiff bases derived from the condensation of 2-hydroxy-1-naphthaldehyde with glycine (L-1) andLβ-alanine (L-2)) was synthesized by reaction of tin(IV) tetraisopropoxide with the ligands, in appropriate stoichiometric ratios (1 : 1 and 1 : 2). This would result in the replacement of the isopropoxide group from the tin(IV) tetraisopropoxide and hydrogen(s) from ligand with the azeotropical removal of isopropanol. An attempt has been made to prove the structure of the resulting complexes on the basis of elemental analysis, IR,1H nuclear magnetic resonance. The binding site of the ligand was identified by IR spectroscopic measurement. In these complexes, the tin(IV) centre is bonded to oxygen atom of the hydroxyl or carboxylate group. The spectra data suggest that the carboxylate group is coordinated to tin(IV) centre in monodentate manner.

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