This nurse-led and specialist-supported assessment and treatment model for inmates with chronic HCV offers potential to substantively increase treatment uptake and reduce the burden of disease.

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We have developed a procedure for immune selection in an established human lymphoid cell line based on HL-A, the major human histocompatibility locus. After a single brief exposure to selective conditions, HL-A2 variant clones were isolated from an HL-A2/HL-A3

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Phosphate frequencies for eight nucleoside 3'3'-and four nucleoside 2',3'-cyclic monophosphates have been determined by Raman and infrared spectroscopy based on comparisons with modified cyclic nucleotides and model cyclic phosphates. To a first approximation the symmetric diester stretching frequency, u,(OPO), is determined by the OPO bond angle. However, substitution on the phosphate ring also affects the frequency and iatensity of v,(OPO). These results are discussed in terms of the use of vJOP0) to determine the degree of backbone order in polynucleotides.