Background: Preeclampsia is a hypertensive disorder associated with substantial perinatal morbidity and mortality. Neonates born to hypertensive mothers are at increased risk of prematurity and foetal growth restriction. Timely prediction and accurate diagnosis is the key to limiting the morbidity and mortality caused by preeclampsia. Early identification of PE using inflammatory biomarkers could reduce PE related comorbidities. Aim: To compare levels inflammatory markers: hsCRP and Lipoprotein(a) levels in preeclamptic pregnant women, with the levels of inflammatory markers among women with normal pregnancy at a tertiary care teaching hospital Material and Methods: This comparative cross-sectional study included 60 Preeclamptic women and 60 apparently healthy singleton pregnant women matched for gestational age and parity. Data was analyzed in SPSS V:16. To find association between inflammatory markers and blood pressure levels, statistical tests like chi-square, independent student t-test were applied. Results: Lp(a) and hsCRP levels were significantly higher among preeclamptic group compared to normal pregnancy group and these levels had moderate positive correlation with SBP (r=0.650) and DBP (0.627) among preeclamptic women. Conclusion: Increased levels of lipoprotein (a) and hsCRP are found in the present study, which are correlating with the progression of preeclampsia by causing endothelial dysfunction and inflammatory cascade. Also, earliest detection of Lp(a) and hsCRP in pregnancy could help to detect preeclampsia and to prevent its further complications.

Pre-eclampsia is defined as development of hypertension and proteinuria (>300 mg in 24 hours urine) after 20 th week of gestation. The presence of proteinuria remains central to the diagnosis of preeclampsia. 24 hours urinary protein measurement is time-consuming and needs more assistance. Spot urinary calcium: creatinine ratio (CCR) has been used to determine the diagnostic accuracy of proteinuria in pre-eclampsia. A case control comparative study was done with women having preeclampsia and normal pregnant women admitted in Gynecology department at Basaveshwara Medical College Hospital, Chitradurga according to the criteria. There was a significant negative correlation between calcium: creatinine ratio and 24-hours urinary proteinuria (r= -0.51). Spot urinary calcium: creatinine ratio at cut off value of 0.18 shows 100% sensitivity and 84% specificity. We conclude that the urinary calcium: creatinine ratio should be considered as a potential alternative for 24-hours urine collection for proteinuria in pregnant women to detect pre-eclampsia.

Subclinical hypothyroidism (SCH) is evaluated as an increased serum thyroid-stimulating hormone (TSH) above the given upper limit of the reference range, with free thyroxine (free T) and free triiodothyronine (free T) within the reference range. Thyroid hormones play major role in the growth, development and physiology of the renal system. The study was performed to evaluate renal functions in SCH cases. The study was conducted at Smt SMS Multispecialty hospital. 50 SCH and 50 overt hypothyroidism (OHT) cases, 100 euthyroid patients (ET) were enrolled in the study. Thyroid function test, serum creatinine and eGFR were measured in all the three groups. The result shows that there was a definitive trend of increased serum creatinine from euthyroid group to SCH group and finally to OHT group and definitive trend of decreased eGFR from euthyroid group to SCH group and finally to OHT group. Among the three groups, there are higher percentage of patients having high serum creatinine and low eGFR belongs to SCH and OHT group in comparison to ET group. Our result showed a significant positive correlation of TSH with serum creatinine in cases of SCH and OHT and significant negative correlation of TSH with eGFR in cases of SCH and OHT. Finding of our study suggests that renal function and thyroid function are interrelated with each other in SCH cases. SCH patients should be monitored for renal parameters regularly to prevent long term complications. Early diagnosis and early treatment of the disease and can increase the quality of life.

Pre-eclampsia is defined as development of hypertension and proteinuria (> 300mg urinary protein in 24hrs urine) after 20 th week gestation. The present study aims to find correlation and usefulness of serum total calcium and uric acid level in preeclampsia. The study was conducted in Basaveshwara Medical College & Hospital from January 2014 to September 2014. Serum Calcium, Uric acid and 24 hours Urinary proteins were estimated. There was a significant decrease in Serum total calcium and increase in serum uric acid in cases of preeclampsia as compare to control group. There was a negative Correlation of serum total calcium and Positive correlation of Serum Uric acid with 24 hour Proteinuria, Systolic & Diastolic Blood Pressure. The study concluded that there was significant hypocalcaemia and hyperuricaemia associated with Preeclampsia. They have greater diagnostic and prognostic value and can be used as screening tests for early prediction of preeclampsia