Diabetes mellitus is the ninth leading cause of death across the globe. Long-term hyperglycemia is associated with hyperlipidemia and oxidative stress. Increased oxidative stress reduces the length of the telomere, which is a biological indicator of aging in humans. Exercise regulates the equilibrium between reactive species generation and antioxidant processes, lowering oxidative stress and risk of chronic disease. Exercise has also been associated with molecular and cellular factors, such as telomere length, which are linked to reducing the risk of disease and improving longevity. Therefore, this review was conducted to appraise regular exercise intervention efficiency in minimizing the DNA damage and preserving telomere length along with genomic stability in various chronic conditions.