Mutations play a fundamental role in the development of cancer, and many create targetable vulnerabilities. There are both public health and basic science benefits from the determination of the proportion of all cancer cases within a population that include a mutant form of a gene. Here, we provide the first such estimates by combining genomic and epidemiological data. We estimate KRAS is mutated in only 11% of all cancers, which is less than PIK3CA (13%) and marginally higher than BRAF (8%). TP53 is the most commonly mutated gene (35%), and KMT2C, KMT2D, and ARID1A are among the ten most commonly mutated driver genes, highlighting the role of epigenetic dysregulation in cancer. Analysis of major cancer subclassifications highlighted varying dependencies upon individual cancer drivers. Overall, we find that cancer genetics is less dominated by high-frequency, high-profile cancer driver genes than studies limited to a subset of cancer types have suggested.

We consider a simple renormalizable model providing a UV completion for dark matter whose interactions with the Standard Model are primarily via the gluons. The model consists of scalar dark matter interacting with scalar colored mediator particles. A novel feature is the fact that (in contrast to more typical models containing dark matter whose interactions are mediated via colored scalars) the colored scalars typically decay into multi-quark final states, with no associated missing energy. We construct this class of models and examine associated phenomena related to dark matter annihilation, scattering with nuclei, and production at colliders.

We explore beyond Standard Model (bSM) physics signatures in the l + jets channel of tt pair production process at the Tevatron and the LHC. We study the effects of bSM physics scenarios on the top quark polarization and on the kinematics of the decay leptons. To this end, we construct asymmetries using the lepton energy and angular distributions. Further, we find their correlations with the top polarization, net charge asymmetry and top forward backward asymmetry. We show that when used together, these observables can help discriminate effectively between SM and different bSM scenarios which can lead to varying degrees of top polarization at the Tevatron as well as the LHC. We use two types of coloured mediator models to demonstrate the effectiveness of proposed observables, an s-channel axigluon and a u-channel diquark.

40 pages, 21 figuresInternational audienceWe study the decay of 125 GeV Higgs boson to light LSP neutralino in the phenomenological minimal supersymmetric standard model in the context of collider searches and astrophysical experiments. We consider the parameter space for light neutralinos that can be probed via the invisible Higgs decays and higgsino searches at the ILC. We consider the cases where the light neutralino is compatible with the observed relic density or where the thermal relic is over-abundant, pointing to non-standard cosmology. In the former case, when the neutralino properties give rise to under-abundant relic density, the correct amount of relic abundance is assumed to be guaranteed by either additional DM particles or by non-thermal cosmology. We contrast these different cases. We assess what astrophysical measurements can be made, in addition to the measurements made at the ILC, which can provide a clue to the nature of the light neutralino. We find that a number of experiments, including Xenon-nT, PICO-250, LZ in conjunction with measurements made at the ILC on invisible Higgs width can pin down the nature of this neutralino, along with its cosmological implications. Additionally, we also point out potential LHC signatures that could be complementary in this region of parameter space