Gastrointestinal stromal tumors (GIST) are a rare and unique group of mesenchymal tumors arising from the gastrointestinal tract, omentum, mesentery, and retroperitoneum. Though they have certain typical radiological features that can differentiate them from epithelial tumors, it is often difficult to differentiate them from other non-epithelial tumors. Their features also vary depending on their size, site of origin, etc. When differentiation from other mesenchymal tumors on histopathology is difficult, receptor tyrosine kinase (C-KIT proto-oncogene/CD117) and gastrointestinal stromal tumor (GIST-1) discovered on GIST1 (DOG-1) expression are confirmatory. The concurrent presence of other primary cancers with GISTs has been described in the literature, among which most have been of gastrointestinal origin. Few cases of primary breast cancer in GIST have been described. Lymph nodal metastasis is rarely encountered in GIST, and metastasis to the breast is even rarer. We present a case of a 39-year-old female with non-specific symptoms who was referred for ultrasonography (USG) and computed tomography (CT) that showed a small intestinal GIST along with a breast lump and axillary lymphadenopathy that were labeled as metastases from the GIST on frozen sections; however, they were later diagnosed as primary breast cancer with axillary metastases on the histopathology and immunohistochemistry of the excision biopsy specimens postsurgery. The patient underwent surgical resection and chemotherapy.

The commonest solid tumour in men between the ages of 15 and 44 is testicular cancer. Germ cell tumours, which are then subdivided into seminomatous and non-seminomatous tumours, are its primary histological kind. In the fourth decade of a man's life, seminoma, accounts for 55% of testicular cancer. Anaplastic seminoma, which accounts for 5% to 15% of testicular seminoma, is an uncommon kind of seminoma. The anaplastic variant of classical seminoma is an uncommon type of seminoma. In order to increase confidence in diagnosing and differentiating benign from the malignant lesion and to localize lesions in the testis, tissue elastography has arisen as a definite, important supplementary method. We present a case report of anaplastic seminoma with its classical imaging findings on strain elastography and its correlation with ultrasound and doppler.