We present highly-excited charmonium, D s and D meson spectra from dynamical lattice QCD calculations with light quarks corresponding to M π ∼ 240 MeV and compare these to previous results with M π ∼ 400 MeV. Utilising the distillation framework, large bases of carefully constructed interpolating operators and a variational procedure, we extract and reliably identify the continuum spin of an extensive set of excited mesons. These include states with exotic quantum numbers which, along with a number with nonexotic quantum numbers, we identify as having excited gluonic degrees of freedom and interpret as hybrid mesons. Comparing the spectra at the two different M π , we find only a mild light-quark mass dependence and no change in the overall pattern of states.

We present a general class of operators resembling compact tetraquarks which have a range of colour-flavour-spin structures, transform irreducibly under the symmetries of the lattice and respect other relevant symmetries. These constructions are demonstrated in lattice QCD calculations with light quarks corresponding to m π = 391 MeV. Using the distillation framework, correlation functions involving large bases of meson-meson and tetraquark operators are computed in the isospin-1 hidden-charm and doubly-charmed sectors, and finite-volume spectra are extracted with the variational method. We find the spectra are insensitive to the addition of tetraquark operators to the bases of meson-meson operators. For the first time, through using diverse bases of meson-meson operators, the multiple energy levels associated with meson-meson levels which would be degenerate in the non-interacting limit are extracted reliably. The number of energy levels in each spectrum is found to be equal to the number of expected non-interacting meson-meson levels in the energy region considered and the majority of energies lie close to the non-interacting levels. Therefore, there is no strong indication for any bound state or narrow resonance in the channels we study.

Elastic scattering amplitudes for I = 0 DK and I = 0, 1 $$ D\overline{K} $$ D K ¯ are computed in S, P and D partial waves using lattice QCD with light-quark masses corresponding to mπ = 239 MeV and mπ = 391 MeV. The S-waves contain interesting features including a near-threshold JP = 0+ bound state in I = 0 DK, corresponding to the $$ {D}_{s0}^{\ast } $$ D s 0 ∗ (2317), with an effect that is clearly visible above threshold, and suggestions of a 0+ virtual bound state in I = 0 $$ D\overline{K} $$ D K ¯ . The S-wave I = 1 $$ D\overline{K} $$ D K ¯ amplitude is found to be weakly repulsive. The computed finite-volume spectra also contain a deeply-bound D* vector resonance, but negligibly small P -wave DK interactions are observed in the energy region considered; the P and D-wave $$ D\overline{K} $$ D K ¯ amplitudes are also small. There is some evidence of 1+ and 2+ resonances in I = 0 DK at higher energies.

Objective The goal of this systematic review was to provide guidelines for treatment parameters regarding electrical stimulation by investigating its efficacy in improving muscle strength and decreasing pain in patients with knee osteoarthritis. Design Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses standard, three electronic databases (CINAHL, PubMed, and PEDro) and gray literature were used. Randomized control trials comparing electrical stimulation and conservative physical therapy were critically appraised using the 2005 University of Oxford standard. Results Nine randomized control trials were included in our review. First, our review confirmed that neuromuscular electrical stimulation is the most effective electrical stimulation treatment in the management of knee OA, and its efficiency is higher when combined with a strengthening program. Second, frequency of at least 50 Hz and no more than 75 Hz with a pulse duration between 200 and 400 μs and a treatment duration of 20 mins is necessary for successful treatment. Conclusions For the first time, our review provides standardized clinical treatment parameters for neuromuscular electrical stimulation to be included in a strengthening program for the adult patient with knee OA. To Claim CME Credits Complete the self-assessment activity and evaluation online at http://www.physiatry.org/JournalCME CME Objectives Upon completion of this article, the reader should be able to: (1) Recall the impact of quadriceps femoris weakness on joint stability; (2) Summarize the mechanism of action of neuromuscular electrical stimulation (NMES) on reducing pain and increasing muscle strength; and (3) Plan the clinical treatment parameters of NMES to be included in a strengthening program for an adult patient with knee osteoarthritis. Level Advanced. Accreditation The Association of Academic Physiatrists is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The Association of Academic Physiatrists designates this Journal-based CME activity for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should only claim credit commensurate with the extent of their participation in the activity.