Tuberculosis (TB) remains one of the deadliest infectious diseases responsible for millions of deaths annually across the world. In developing countries the incidence of tuberculosis has been increasing steadily, the most serious infectious causes of all the global mortality and morbidity. The principle aim is to assess the prescribed Tuberculosis treatment and curative outcome of patients registered for Tuberculosis treatment. A Prospective Observational study was conducted in Tuberculosis Unit of Pulmonology Department, Sri Venkateswara Ramnarain Ruia Government General Hospital, a tertiary care hospital in Tirupathi, Andhra Pradesh, India for 6 months duration with a sample size of 150. In this study male were predominant with 87 (58%), age group of 41-60 years were predominant. Pulmonary Tuberculosis cases were 136 and Extra Pulmonary Tuberculosis was 14; the patients with Diabetes Mellitus (45%), HIV (24%), Alcohol (28%) and Smoking (40%). The cases under category I and II were 100 and 50; the sputum positive, sputum negative and sputum not done were 127, 14 and 9 respectively. The sputum score was 1 in 16, 2 in 53, and 3 in 58. Treatment success rate was 81%, treatment failure was 3%, defaulter, transferred out and mortality rate were found to be 6%, 4% and 6% respectively. Despite of success rate we still observe considerable rate of treatment failure due to resistance, non-compliance totreatment and lack of awareness in the patients about importance of Tuberculosis treatment. Further efforts should be made by responsible bodies to include clinical pharmacists to improve success rate of Tuberculosis treatment, as clinical pharmacist play a key role in educating the patients.