Introduction: Academic stress is anxiety and stress that comes from schooling and education. There is often a lot of pressure that comes along with pursuing a degree and one’s education. Methods: A descriptive cross-sectional study design was used to find out academic stress and relationship of academic stress with parent-adolescent relationship, and academic achievement which was conducted in two college of Kathmandu Metropolitan. Study populations were students of the management stream who were studying in class XII. This study adopted non probability purposive sampling method to select college of Kathmandu metropolitan whereas simple random sampling with lottery method was used to select sample of 253 students. Data was coded, categorized and then entered into SPSS 16 and analyzed using both descriptive and inferential statistics. Results: The findings revealed that nearly half of the respondents (47%) had moderate academic stress and 23.7% have high academic stress. Regarding overall level of relationship with both parents more than half of the respondents (64.4%) have favorable relationship. There is significant relationship between academic stress, academic achievement of previous level and association was seen between academic stress and mother’s education. Students have moderate and high academic stress in their academic path. Irrespective of parent adolescent relationship, majority of adolescent had low or moderate academic stress, research hypothesis was rejected. Respondents who have scored higher grade or academically achieved comparatively had high academic stress, research hypothesis was accepted. Conclusions: Academic staffs and related concerned authorized individual need to identify early as interventions to assess students' academic stress, in order to reduce academic stress, helps to improve the quality of life and mental health for students.