The study was carried out to evaluate propofol and ketamine CRI in dexmedetomidine and butorphanol pre-medicated dogs undergoing elective ovariohysterectomy. Animals were randomly divided into two Groups (A and B) comprising six animals in each. All the animals were administered glycopyrrolate @ 0.01 mg/kg IM. Fifteen minutes later dexmedetomidine 5µg/kg IV and butorphanol 0.1mg/kg IV and two minutes later induction and maintenance of anaesthesia was done with propofol in Group A and ketamine in Group B. The mean induction times (Sec) in Group A and B were recorded as 34.67 ± 2.12 and 36.67±1.63, respectively. The induction doses of propofol and ketamine were recorded as 0.68± 0.06 and 2.63±0.26 mg/kg, respectively. The recovery time were recorded as 10.25±0.44 and 14.83±1.26 min in Group A and B, respectively. The maintenance dose of propofol and ketamine for CRI were recorded as 0.24±0.01 and 0.013±0.60 mg/kg/min, respectively in Group A and B. Quality of anaesthesia was excellent in both the group and the clinical parameters remained with the physiological limit.