Objectives To define endoscopic and histological remission in ulcerative colitis (UC) accurately, several scoring systems have been established. A novel virtual electronic chromoendoscopy score, the Paddington International Virtual ChromoendoScopy ScOre (PICaSSO), was developed, validated, and reproduced to assess inflammation grade and predict patient prognosis. We externally verified and validated the clinical value of PICaSSO in UC patients. Methods This prospective study enrolled 63 UC patients. The Mayo endoscopic score (MES), UC Endoscopic Index of Severity (UCEIS), and PICaSSO were adopted for endoscopic evaluation. All biopsy samples were scored using the Robarts histological index (RHI), Nancy histological index (NHI), and “Extent, Chronicity, Activity, Plus additional findings” (ECAP) score. Patients with an endoscopic MES of 0–1 at baseline were followed up during a median time of 23.5 months. Results PICaSSO was strongly correlated with other endoscopic and histological scoring systems. PICaSSO ≤3 had advantages in assessing histological remission (HR), with the highest accuracy of 88.9% for ECAP‐HR. Relapse‐free survival rates were significantly different between patients with MES 0 and MES 1 and patients with PICaSSO ≤3 and >3 (P = 0.010 and 0.018, respectively). Conclusions PICaSSO was externally validated with strong correlations with other endoscopic and histological scoring systems in UC, and PICaSSO‐ER might potentially predict a better long‐term clinical outcome in UC patients.

AimAutoimmune pancreatitis (AIP) is a rare and enigmatic immune‐mediated inflammatory diseases associated with inflammatory bowel disease (IBD). We aimed to describe the prevalence, characteristics, and associated factors of AIP‐IBD patients in China.MethodsWe performed a retrospective bidirectional case–control study from 1998 to 2021. The diagnosis of IBD was based on the European Crohn's and Colitis Organisation guidelines and of AIP was based on the International Consensus Diagnostic Criteria. IBD controls were matched by age (±1), sex, and IBD type at a ratio of 1:4, while AIP controls were matched by the frequency of AIP types.ResultsThe age‐standardized prevalence of AIP‐IBD patients in the IBD and AIP population were 292.04 and 8151.93 per 100 000, respectively. IBD patients had a higher risk of suffering AIP compared to non‐IBD patients (OR: 8.4, CI: 4.7–14.9, p < 0.0001), as well as AIP patients developing IBD compared to general population in China. The mean age at diagnosis of IBD was 34.8, and of AIP was 50. Seven cases were first diagnosed with IBD, and the average IBD duration was 94.8 months, while 26.1 months for AIP. Independent factors associated with AIP was tuberculosis infection (p < 0.0001). The occult blood test (p = 0.008) was independently associated with IBD.ConclusionsWe found most AIP‐IBD patients had UC or type 2 AIP. The IBD population is more likely to develop AIP compared to the general population, vice versa. Tuberculosis infection were associated with AIP, and occult blood test was associated with IBD.This article is protected by copyright. All rights reserved.

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