BackgroundThe global cancer burden is estimated to have risen to 18.1 million new cases and 9.6 million deaths in 2018. The period of child's diagnosis negatively influences parents socially and psychologically leading to depression.ObjectivesThe aim of the study was to assess the prevalence of depression, its associated factors and parent's experience towards care of their cancer diagnosed child.MethodsA mixed approach quantitative and qualitative cross‐sectional study was employed between 15 March and 1 April 2017. Systematic random sampling involving 275 participants in the quantitative and 20 conveniently selected participants for qualitative study were included in the study. Beck's depression inventory scale was used to collect data. Logistic regression including bivariate and multivariate analysis considering 95% confidence interval (CI) was utilized to examine association between dependent and independent variables. P‐value <.05 was considered statistically significant. Thematic analysis was used to analyze qualitative data.ResultsThe prevalence of depression among parents was 72.4%, with depression levels of: borderline 7.3%, moderate 6.2%, severe 6.5%, and extreme severe depression 3.3%. Single parenting, income, history of depression, and support source were associated with parental depression (adjusted odds ratio, AOR = 6.21; 95% CI: 2.66‐14.52), (AOR = 0.34; 95% CI: 0.02‐0.86), (AOR = 8; 95% CI: 1.7‐37.4), (AOR = 38; 95% CI: 2.6‐560), respectively.ConclusionFamily income, single parenting, and support sources are determinant factors for parental depression in this study. Nurses should early detect parents at risk and give due attention to reduce the risk of depression.