Burns can be caused by heat or other acute trauma, currently the number of cases is still high in Indonesia and the world. The advances of burns treatment are made through research on possible natural ingredients. Flavonoids are polyphenolic compounds that are most commonly found in plants and as well as possible in burn healing. The aims of this literature review are decribed burns, histological structure of skin, and the effectiveness of flavoinoids in burns healing. The method used in this literature review is by searching data through the Science Direct, PubMed, and Google chrome databases. The search results of 19 appropriate journals, it was found that the flavonoid compounds can heal burns through their ability to inhibit prostanoid biosynthesis, inhibition of phosphodiesterase, and various other important mechanisms.