Neonatal sepsis is a clinical syndrome that involves a systemic infection of the newborn during the first 28 days of life, with a high contribution of zoonotic sources worldwide. Sepsis is not, therefore, a monolithic condition. It encompasses a spectrum of illnesses that range from minor signs and symptoms to organ dysfunction and shock. Infection may occur by hematogenous, transplacental spread from a mother or by ascending infection from the cervix. Commonly, it is classified as early-onset (day of life 0-3) or late-onset (day of life 4 or later). The risk of acquiring the infection may be increased by maternal bacterial colonization, poor nutrition, exposure to animals, and poor hygiene.Infection is a major cause of mortality during the first month of life and the mortality rate is still very high and extensively varies by setting. The prevalence of the infection is reported to have advanced in low-and middle-income countries more than in developed countries. In African countries like Egypt, Tanzania, South Africa, Nigeria, and Ethiopia, the prevalence of the disease has been remarkably reported to be higher.The microbes that remain human competitors for dominance of the planet continue to cause neonatal sepsis. Globally, the most common isolated causative agents of neonatal sepsis were Escherichia coli, Staphylococcus aureus, and Klebsiella pneumonia, though Acinetobacter, Campylobacter jejuni, Shigella, and salmonella are also common. Given the diversified causes, less is known about host response to neonatal sepsis compared with other ages, particularly in relation to zoonotic diseases. However, immune system activation and inflammation are the major pathways leading to infectious and non-infectious stimuli. Regardless of the body response, establishing the diagnosis of neonatal sepsis using a clinical approach remains a commonly accepted practice. But different options are available to diagnose, implicate the present condition, and predict the prognosis. Conclusion:Generally, while the need for an urgent commencement of antibiotics is one of the most pressing concerns in the control of an infection, a simple wash can be all that is needed to ensure your health is not compromised.