Background Combining the multimodal imaging and synergistic treatment in one platform can enhance the therapeutic efficacy and diagnosis accuracy. Results In this contribution, innovative Mn-doped Prussian blue nanoparticles (MnPB NPs) were prepared via microemulsion method. MnPB NPs demonstrated excellent T1 and T2 weighted magnetic resonance imaging (MRI) enhancement in vitro and in vivo. The robust absorbance in the near infrared range of MnPB NPs provides high antitumor efficacy for photothermal therapy (PTT) and photoacoustics imaging property. Moreover, with the doping of Mn, MnPB NPs exhibited excellent Fenton reaction activity for chemodynamic therapy (CDT). The favorable trimodal imaging and Fenton reaction enhanced mild temperature photothermal therapy in vitro and in vivo were further confirmed that MnPB NPs have significant positive effectiveness for integration of diagnosis and treatment tumor. Conclusions Overall, this Mn doped Prussian blue nanoplatform with multimodal imaging and chemodynamic/mild temperature photothermal co-therapy provides a reliable tool for tumor treatment. Graphical Abstract

A lysosome-targeting NIR photosensitizer has been developed for two-photon fluorescence imaging and imaging-guided photodynamic therapy via lysosomal-damage-mediated apoptosis.

Nanomaterials-related photothermal therapy has been intensively investigated in treatment for hepatocellular carcinoma (HCC). However, owing to the low specificity to tumor and easy excretion from the systemic circulation, the low...

To investigate the effect of an injectable calcium alginate-amelogenin hydrogel on the polarizability of macrophages and its mechanism of effectively mediating the bone immune microenvironment and improving the osteogenic efficacy of jaw and facial bone defect areas. In this study, we prepared an injectable calcium alginate-amelogenin hydrogel using calcium alginate loaded with amelogenin and investigated its physical properties through cellular experiments. The experimental results showed that the material is injectable, biocompatible, degradable, anti-inflammatory, and promotes osteogenesis. This project provides new ideas for formulating bone tissue regeneration materials and promotes their clinical translation.