Background: Mechanical forces regulate gene expression. The mechanisms are not well understood. Results: A HES-1 site in the promoter of h2-calponin gene is a tension-regulated repressor responsive to Notch signaling. Conclusion: Notch regulation plays a role in the mechanoregulation of h2-calponin. Significance: The findings demonstrated a novel mechanism in the mechanoregulation of h2-calponin gene expression.
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