Seventy-six patients took part in a randomized, comparative study of the efficacy of buflomedil hydrochloride and dihydrogenated ergot alkaloids in the treatment of senile dementia associated with cerebrovascular insufficiency. Efficacy was assessed by the patients' performance in four psychometric tests. The results showed that a trend in favour of the buflomedil group in three of the tests became statistically significant in the fourth. Both drugs appeared to be safe, causing no marked adverse reactions. In conclusion, buflomedil is as effective or more effective than dihydrogenated ergot alkaloids in the treatment of senile dementia associated with cerebrovascular insufficiency and could prove a valuable addition to long-term therapy if further studies support the trend shown in this study.

The objective of this double-blind trial was to assess the effect of diclofensine on geriatric patients with depressive syndromes in comparison to placebo. 40 patients (age 60-75 years) were treated for 3 weeks with a mean daily dose of 57.5 mg diclofensine or placebo. Diclofensine was found effective in 18 (= 90%) cases (placebo 60%) after 2.9 days on an average (placebo, 4.2 days), mostly having a mood elevating effect and in only 2 cases (placebo 1) having a stimulatory effect. The results of the global assessments, the Hamilton depression scale, the d2-test, the block design test and the mood scale (Befindlichkeitsskala) demonstrated a statistically significant superiority of diclofensine over placebo. The critical flicker frequency, on the other hand, was not able to differentiate significantly between the two drugs. The tolerance was considered as very good in all cases. Unwanted effects were observed in 13 patients (= 65%) of the diclofensine group and in 9 patients (= 45%) of the placebo group. They disappeared in most cases within one week after their appearance. According to this trial diclofensine can be described as a well tolerated drug without pronounced anticholinergic side effects, capable of improving depressive states faster and more effectively than placebo.

Brückner, Georg: Der Rennstieg in seiner historischen Bedeutung — oder: war das obere Werra- und Mainland jemalsThüringisch?, in: Neue Beiträge zur Geschichte deutschen Alterthums. Herausgegeben vom Hennebergischen alterthumsforschendenVerein. Bd. 3, Meiningen 1867, S. 247-285.

Am 17. 1. 1924 wurde der l6jährige Bergmann Joseph R. in meiner Abteilung aufgenommen mit den Erscheinungen eines hochgradigen Hydrops. Beide Beine waren elefantiastisch ödematös geschwollen, das Oesicht war gedunsen, die Arme zeigten leichte ödematöse Schwellung, die Bauchdecken Anasarka, der Leib war durch den hydropischen Aszites stark ausgedehnt, es bestand Atemnot durch llochdrängung des Zwerchfells, während im Thorax und Perikard 1-lydrops nicht nachweisbar war, was auch die Röntgendurchleuchtung bestätigte. R. war früher gesund gewesen und hatte die Anschwellungen angeblich seit Mitte Oktober 1923 nach einer Phirnosen-Operation beobachtet; dagegen will er vermehrten Durst und Urin bereits einige -Monate vorher bemerkt haben. Die Untersuchung am Herz-und Oefäßsystem ergab außer einen (dauernd) niedrigen