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Abstract. In acute and subehronie inhalation studies rats were exposed to trichloroethylene. During the 4-h exposures the concentration was about 50 ppm to 3t60 ppm and more, and in the 14-week study (8 h/day) within the range of the MAC (50 ppm). The behavior of triehloroethylene and its metabolites (chloral hydrate, trichloroethanol and trichloroacetic acid) in the expired air, blood and urine was investigated. For this purpose, analytical methods were developed.With the exception of elevated liver weights, the exposure to a trichloroethylene concentration of 55 ppm over a period of 14 weeks did not cause any p~hologieal changes. The liver enlargement as a consequence of an enzyme induction is discussed. Trichloroethylene was not detectable in the blood, and the concentrations of trichloroethanol and chloral hydrate were not altered significantly. The urinary triehloroethanol excretion increased until the 10 th week and then decreased slowly. In contrast, the trichloroacetic acid remained fairly constant. Corresponding results of the ratio TCE: TCA were found.

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