In this study, with our technique of filtering out projection-related imaging errors, computer-assisted implantation of total knee replacements improved the frontal and sagittal alignment of the femoral component but not of the tibial component. We found that the rotational alignment of the component was not improved through navigation by solely referencing to the epicondylar axis for the femur and the tuberosity for the tibia.

Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.

The underlying mechanism appears to be dependent on the FGFR and VEGFR signaling cascades and might be mediated by an additional cross-talk with other pathways. STEM CELLS 2007;25:903-910 Disclosure of potential conflicts of interest is found at the end of this article.

The present data do not support the assumption that there is a correlation between varus malalignment and a bad medium-term radiological and clinical outcome after total knee arthroplasty. This questions the indication for revision of painful and varus malaligned prostheses, since an improvement of the clinical outcome is not to be expected.

No abstract