The availability of fast and robust algorithms for protein structure comparison provides an opportunity to produce a database of three-dimensional comparisons, called families of structurally similar proteins (FSSP). The database currently contains an extended structural family for each of 154 representative (below 30% sequence identity) protein chains. Each data set contains: the search structure; all its relatives with 70-30'70 sequence identity, aligned structurally; and all other proteins from the representative set that contain substructures significantly similar to the search structure. Very close relatives (above 70% sequence identity) rarely have significant structural differences and are excluded. The alignments of remote relatives are the result of pairwise all-against-all structural comparisons in the set of 154 representative protein chains. The comparisons were carried out with each of three novel automatic algorithms that cover different aspects of protein structure similarity. The user of the database has the choice between strict rigid-body comparisons and comparisons that take into account interdomain motion or geometrical distortions; and, between comparisons that require strictly sequential ordering of segments and comparisons, which allow altered topology of loop connections or chain reversals. The data sets report the structurally equivalent residues in the form of a multiple alignment and as a list of matching fragments to facilitate inspection by three-dimensional graphics. If substructures are ignored, the result is a database of structure alignments of full-length proteins, including those in the twilight zone of sequence similarity. The database makes explicitly visible architectural similarities in the known part of the universe of protein folds and may be useful for understanding protein folding and for extracting structural modules for protein design. The data sets are available via Internet.

The scientific need for a standard protocol permitting the exchange of generic observing services is rapidly escalating as more observatories adopt service observing as a standard operating mode and as more remote or robotic telescopes are brought on-line. To respond to this need, we present the results of the first interoperability workshop for Heterogeneous Telescope Networks (HTN) held in Exeter. We present a draft protocol, designed to be independent of the specific instrumentation and software that controls the remote and/or robotic telescopes, allowing these telescopes to appear to the user with a unified interface despite any underlying architectural differences.

The first of two 1.2m MONET robotic telescopes became operational at McDonald Observatory in Texas in spring 2006, the second one will be erected at the South African Astronomical Observatory's Sutherland Station. About 60% of the observing time is dedicated to scientific use by the consortium (Univ. Göttingen, McDonald Obs. & the South African Astron. Obs.) and 40% is for public and school outreach. The alt-az-mounted f/7 RC imaging telescopes are optimized for fast operations, with slewing speeds up to 10°/sec in all axes, making them some of the fastest of their class in the world. The unusual clam-shell enclosures provide the telescopes with nearly unobstructed views of the sky. The new observatory control system fully utilizes the hardware capabilities and permits local, remote, and robotic operations and scheduling, including the monitoring of the weather, electric power, the building, current seeing, all software processes, and the archiving of new data.

Remote Telescope Markup Language (RTML) is an XML-based interface/document format designed to facilitate the exchange of astronomical observing requests and results between investigators and observatories as well as within networks of observatories. While originally created to support simple imaging telescope requests (Versions 1.0-2.1), RTML Version 3.0 now supports a wide range of applications, from request preparation, exposure calculation, spectroscopy, and observation reports to remote telescope scheduling, target-of-opportunity observations and telescope network administration. The elegance of RTML is that all of this is made possible using a public XML Schema which provides a general-purpose, easily parsed, and syntax-checked medium for the exchange of astronomical and user information while not restricting or otherwise constraining the use of the information at either end. Thus, RTML can be used to connect heterogeneous systems and their users without requiring major changes in existing local resources and procedures. Projects as very different as a number of advanced amateur observatories, the global Hands-On Universe project, the MONET network (robotic imaging), the STELLA consortium (robotic spectroscopy), and the 11-m Southern African Large Telescope are now using or intending to use RTML in various forms and for various purposes.

Remote Telescope Markup Language (RTML) is an XML-based protocol for the transport of the high-level description of a set of observations to be carried out on a remote, robotic or service telescope. We describe how RTML is being used in a wide variety of contexts: the transport of service and robotic observing requests in the Hands-On Universe™, ACP, eSTAR, and MONET networks; how RTML is easily combined with other XML protocols for more localized control of telescopes; RTML as a secondary observation report format for the IVOA's VOEvent protocol; the input format for a general-purpose observation simulator; and the observatory-independent means for carrying out request transactions for the international Heterogeneous Telescope Network (HTN).