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Considerable evidence supports the role of oxidative stress in adult type 2 diabetes (T2D). Due to increasing rates of pediatric obesity, lack of physical activity, and consumption of excess food calories, it is projected that the number of children living with insulin resistance, prediabetes, and T2D will markedly increase with enormous worldwide economic costs. Understanding the factors contributing to oxidative stress and T2D risk may help develop optimal early intervention strategies. Evidence suggests that oxidative stress, triggered by excess dietary fat consumption, causes excess mitochondrial hydrogen peroxide emission in skeletal muscle, alters redox status, and promotes insulin resistance leading to T2D. The pathophysiological events arising from excess calorie-induced mitochondrial reactive oxygen species production are complex and not yet investigated in children. Systems medicine is an integrative approach leveraging conventional medical information and environmental factors with data obtained from “omics” technologies such as genomics, proteomics, and metabolomics. In adults with T2D, systems medicine shows promise in risk assessment and predicting drug response. Redoxomics is a branch of systems medicine focusing on “omics” data related to redox status. Systems medicine with a complementary emphasis on redoxomics can potentially optimize future healthcare strategies for adults and children with T2D.

An optimization system that supports the production of concrete while minimizing carbon dioxide (CO 2 ) emissions or costs is presented that incorporates an evolution algorithm for the materials' mix design stage, a trigonometric function for the transportation stage, and a stochastic model for the manufacturing stage. A case study demonstrates that applying the optimization system reduced CO 2 emissions by 34% compared to the standard concrete production processes typically used. When minimizing the cost of concrete production was prioritized, the cost dropped by 1% compared to the cost of conventional concrete production. These findings confirm that this optimization system helps with the design of the concrete mix and the choice of a material supplier, thus reducing both CO 2 emissions and costs.