Objective
This study examined heel ultrasonography, levels of 25-OHD, and levels of urinary NTX-I in patients with a recent osteoporotic hip fracture to see if they were clinically useful.
Methods
T scores of stiffness index(SI) obtained from quantitative heel ultrasound(QUS), levels of serum 25-hydroxyvitamin D(25-OHD) and levels of urine N-terminal cross linking telopeptide of type I collagen(NTX-I) were obtained in 53 female and 32 male hip fracture patients. Sixty five female patients and five male patients attending our geriatric clinic were used for comparison.
Results
The T scores of SI of the hip fracture patients were less than those of the geriatric clinic patients. The difference was signficant in females(p = 0.0001), but not in males (p = 0.1). Serum levels of 25-OHD were less than 28 ng/ml in 50 out of 59 patients, and less than 5 ng/ml in two patients. Levels of urinary NTX-I were variable, and were not correlated with other parameters.
Conclusions
Patients who have sustained a hip fracture have a low SI determined by QUS; this is easy to perform and it provides a baseline T score from which to assess treatment effects. The majority of these patients are vitamin D deficient and measurement of the level of 25-OHD would enable physicians to prescribe an appropriate dose of vitamin D. Urine NTX-I measured shortly after a hip fracture is not clinically helpful.
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