Four hundred sixty-six female patients were enrolled in a randomized study that compared the clinical efficacies of single oral doses of cefuroxime axetil and amoxicillin with probenecid in the treatment of uncomplicated gonorrhea. Two hundred ninety-five patients had culture-positive gonococcal infections and completed the investigation. Cure rates for the patients treated with cefuroxime axetil and those treated with amoxicillin with probenecid were high (>95%) for genitorectal infections. Pharyngeal infections, however, were not uniformly eradicated by either cefuroxime axetil (60%) or amoxicillin with probenecid (64%). Approximately 13% of each patient group suffered adverse events, which were gastrointestinal in the majority and were transient. Compared with amoxicillin plus probenecid, cefuroxime axetil in a single oral dose was an equally safe and effective drug for the treatment of uncomplicated gonorrhea in women caused by penicillin-susceptible strains.Earlier studies (3, 4, 8-10, 12, 14, 16) examining the treatment of uncomplicated gonorrhea with a single dose of parenteral cefuroxime with and without oral probenecid demonstrated that this regimen was efficacious and well tolerated. Cefuroxime axetil, the ester prodrug of cefuroxime, was also shown to be effective (2,5,13,18) in the treatment of uncomplicated gonorrhea when administered in a single oral dose, with and without probenecid. Although these investigations with cefuroxime axetil provided much information on the treatment of urethral infections in men, the studies enrolled relatively few women. We therefore examined the efficacy of single-dose cefuroxime axetil in a large number of women with uncomplicated gonorrhea who were seen at sexually transmitted disease clinics of four different city or county health departments.

No abstract

No abstract

No abstract

No abstract