Bone regeneration is a claim challenge in addressing bone defects with large tissue deficits, that involves bone grafts to support the activity. In vitro biocompatibility of the bacterial cellulose-modified polyhydroxyalkanoates (PHB/BC) scaffolds and its osteogenic potential in critical-size mouse calvaria defects had been investigated. Bone promotion and mineralization were analyzed by biochemistry, histology/histomorphometry, X-ray analysis and immunofluorescence for highlighting osteogenesis markers. In summary, our results showed that PHB/BC scaffolds are able to support 3T3-L1 preadipocytes proliferation and had a positive effect on in vivo osteoblast differentiation, consequently inducing new bone formation after 20 weeks post-implantation. Thus, the newly developed PHB/BC scaffolds could turn out to be suitable biomaterials for the bone tissue engineering purpose.

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Addiction is a wide spread term used in our days. Some of the habits due to routine conditioning are called dependences, i.e.: eating shopping etc. These are fundamentally different of those due to chronic alcohol intake, drugs medicines (chemicals), with euphoric effect. For this reason some physicians prefer the term of addiction to drug. Unlike the benign addiction, by conditioning, drugs addiction initiates very fast (after 1 or 2 intakes), had a big resistance at treatment and show the phenomena of sever disturbance in withdrawal. In this paper we refer mainly at this kind of dependency. Nervous disturbances that are produced during drugs and even alcohol intakes refer to psychical affective and cognitive processes. The prevailing factor of these processes is the hedonist one.

Introduction: Abdominal cystic lesions can be localized either in parenchymal or non-parenchymal organs and can be acquired or congenital. Knowing the characteristic imaging features as well as demographic data and the prevalence of cystic lesions can help radiologists in establishing the correct diagnosis. In this article, we conducted a statistical study of congenital and acquired cystic lesions of the abdomen, diagnosed by CT scan in patients hospitalized in Emergency Clinical County Hospital of Constanţa in years 2019 - 2020. Material and methods: The retrospective study included 285 patients admitted to the hospital. In the case of each patient, we recorded the following variables: Age, Sex, Localization of the lesion, Types of cysts for each localization. Results: The average age of the patients is 61.53 years. Most of the cystic lesions were localized in the liver (182 cases) and they were represented by: hydatid cysts, simple hepatic cysts, hepatic abscess, hepato-renal polycystic disease and hepatic adenocarcinoma. Cystic lesions of the kidney (56 cases) were represented by: autosomal dominant polycystic kidney disease, renal carcinoma, simple renal cysts, acquired polycystic renal disease, tuberous sclerosis, clear cell renal carcinoma and von Hippel Lindau syndrome. Cystic lesions of pancreas (47 cases) were represented by: pancreatic cysts, pancreatic pseudocysts and pancreatic adenocarcinoma. Conclusions: CT examination is extremely useful in establishing the location, type, imaging characteristics of cystic lesions, echo over surrounding organs, possibility of malignant transformation. The prevalence of certain types of localizations and morphologies depending on the age and organ involved always helps to obtain a correct and rapid diagnosis.