We use the intra-arterial route with 4 objects in view: (1) Analgesic action.(2) Vasodilatory action. (3) Antibiotic action. (4) Anticoagulant action.Analgesic. Procaine hydrochloride is preferred with direct action and greater tolerance than by any other route. Vasodilatory. Intra-arterial injections of any medicament induce a transitory vasoconstrictor phenomenon and secondarily a vasodilatation which varies in intensity in proportion to the intensity of the vasoconstrictor phenomenon. The vasomotor phenomena to which we have made reference are null when procaine is used as a vehicle. They are very intense when hypertonic solutions above 25 per cent are used. The secondary vasodilatation we have referred to, induced by procaine or with such drugs as Priscol, Hydergine, Roniacol, etc., is of great importance since a greater degree of irrigation is obtained in the sector where it is needed (hemometakinesia).Milan6s-L6pez and his collaborators have proved this in recent experiments, taking 20 patients with peripheral vascular disorders, thromboangiitis obliterans and arteriosclerosis obliterans. In 10 of these cases various vasodilatator drugs-Lambral, Priscol, Hydergine, Roniacol-were used intramuscularly and intravenously, and it was observed that these vasodilators did not modify the cutaneous temperature of the limb in which the circulation was more precarious but, on the contrary, raised the temperature in the healthy member by more than 4°C. The remaining 10 cases were treated by prolonged regional vasodilatation and an increase was obtained in the cutaneous temperature of the affected limb which demonstrated conclusively the truth of the phenomenon of hemometakinesia described by DeBakey and his collaborators in 194'T.1Antibiotic. The sanguineous concentrations obtained by the intra-arterial at Harvard Libraries on June 26, 2015 ang.sagepub.com Downloaded from

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