Basal cell carcinoma (BCC) is known as the most common type of nonmelanoma skin cancer worldwide. The aim of this study is to show the effectiveness of photodynamic therapy and cryotherapy in patients with BCCs with the use of meta-analyses in order to see if there is a possible superiority of one treatment over the other. We searched the databases PubMed, MEDLINE, CINAHL, Scopus, OVID, Embase, Science Direct, JAMA Dermatology, and Research Gate in April 2020. The search combined related terms for cryotherapy, BCC, cryosurgery, cryoablation, laser and photodynamic therapy. The comparison of photodynamic therapy (PDT) vs cryotherapy on recurrence rate yielded no statistically significant results (Figure 2; N = 3 randomized control trials [RCTs]; Summary Random Effects OR = 4.99; P = .212). We observed large heterogeneity (I 2 = 87.3%), but no indication for small study effects (Egger's test, P = .02). Regarding the comparison of PDT vs cryotherapy on complete response, again no statistically significant results were observed (Figure 3; N = 2 RCTs; Summary Fixed Effects OR = 0.83; P = .538) and no indication of heterogeneity (I 2 = 0%). Our meta-analyses indicated that the comparison of PDT vs cryotherapy has no statistically significant results. Therefore, these therapies seem to have similar therapeutic effects.

Actinic keratoses (AKs) are the most common neoplastic lesions and are recognized as a precursor to squamous cell skin cancer. Photodynamic therapy (PDT) is a therapeutic option for multiple AKs in line with field cancerization. The aim of this study was to assess the effectiveness of PDT on patients with AKs using a meta-analysis, in order to evaluate the possible superiority of one treatment over the others. For this purpose, the PubMed, MEDLINE, Scopus, OVID, Science Direct, British Journal of Dermatology, Research Gate, and Embase databases were searched in March 2022. The search terms used were 'photodynamic therapy' and 'actinic keratosis'. We utilized the random-effects meta-analysis model to compare methyl aminolevulinate PDT (MAL-PDT) and the combination of a nanoscale-lipid vesicle formulation with the prodrug 5-aminolevulinic acid (BF-200 ALA) on a complete response (CR) of the lesions. Our meta-analysis indicated that the comparison of BF-200 ALA versus MAL-PDT showed marginally higher CRs than MAL-PDT.