P lain ropivacaine administered intrathecally has been shown to be feasible for ambulatory surgery of the lower extremities. Hypothetically, hyperbaric solution could improve and shorten the block.This prospective, randomized, double-blind study included 56 patients undergoing surgery of the lower extremities. They received intrathecally either 1.5 mL of ropivacaine 10 mg/mL and 0.5 mL of glucose 300 mg/mL (HYP) or 2 mL of ropivacaine 7.5 mg/mL (PL).T 10 analgesia was achieved in all patients in Group HYP, but only 64% (18/28) of Group PL achieved this level of analgesia. In the HYP group, T 10 analgesia was reached in 5 minutes (median, range 5-20 minutes) compared with 10 minutes (5-45 minutes) in the PL group (P = 0.022), and full motor block in 10 minutes (5-45 minutes) compared with 20 minutes (5-60 minutes) (P = 0.003), respectively. Group HYP had a longer duration of analgesia at T 10 (83 minutes [5-145 minutes] vs. 33 minutes [0-140 minutes]) (P = 0.004). Duration of sensory block from injection of the local anesthetic to complete recovery was briefer in Group HYP than in Group PL, 210 minutes (120-270) compared with 270 minutes (210-360 minutes) (P < 0.001). Patients of Group HYP attained discharge criteria earlier than those of Group PL (P = 0.009). The investigators concluded that 15 mg of intrathecal hyperbaric ropivacaine produced a faster onset, greater success rate of analgesia at the level of T 10 dermatome, and faster recovery of the block.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.