Hereditary hemochromatosis (HH) is an autosomal recessive disorder with low penetrance and seems to be the most common genetic condition in people of European descent. 1 It is now more often diagnosed due to genetic testing in context of familial history, high ferritin levels or non-specific symptoms as fatigue, lethargy, articular, and bone complaints. Organs classically known to be affected by hemochromatosis include the liver, pancreas, heart, thyroid, joints, skin, gonads, and pituitary.There are few studies reporting a higher prevalence of osteoporosis and vertebral fractures in these patients, especially in men. Although the pathophysiology of this complication is complex and still in process of being revealed, 2 the targeted treatment remains the same as for the primary osteoporosis, with a significant impact on fracture risk reduction and improvement of quality of life. | CASE REPORTA 55-year-old male patient was referred to our Metabolic Bone Diseases Clinic for severe osteoporosis with multiple vertebral fractures. The patient's medical history was positive for chronic lumbar pain and arterial hypertension, for which he was treated with indapamide, enalapril and lercanidipine. The osteoporosis was incidentally discovered when he presented to the emergency department with severe, invalidating back pain, that started the day after some light gardening, with no history of trauma. The physical examination was unremarkable except for a height loss of 7 cm in the last 5 years. The thoraco-lumbar X-ray and lumbar magnetic resonance imaging (MRI) showed a 5-level severe compression vertebral fractures with collapse of the superior endplates of T11, T12, L2, L3 and L4 (Figure 1). Whole body scintigraphy showed recent T11, T12, and L1 fractures, older L2-L4 fractures and fractures of the

Symptoms of mild hypoglycemia are easily overlooked especially when there are no complaints from the patients, but it could be a warning sign of an underlying genetic disease. Genetic testing for the entire family is a key step in neonatal hypoglycemia workup.

Congenital adrenal hyperplasia associated to 11‐beta‐hydroxylase deficiency is a rare cause of secondary hypertension, usually discovered during childhood; however, a late diagnosis in adults has also been reported. Despite low cortisol levels, accumulated adrenal steroid precursors can activate the glucocorticoid receptor and thus protect the patient against adrenal crisis.