eXfiltration Advanced Persistent Threats (XAPTs) increasingly account for incidents concerned with critical information exfiltration from High Valued Targets (HVTs). Existing Cyber Defence frameworks and data fusion models cannot cope with XAPTs due to a lack of provision for multi-phase attacks characterized by uncertainty and conflicting information. The Markov Multi-phase Transferable Belief Model (MM-TBM) extends the Transferable Belief Model to address the multi-phase nature of cyber-attacks and to obtain previously indeterminable Cyber SA. As a data fusion technique, MM-TBM constitutes a novel approach for performing hypothesis assessment and evidence combination across phases, by means of a new combination rule, called the Multi-phase Combination Rule with conflict Reset (MCR 2). The impact of MM-TBM as a Cyber Situational Awareness capability and its implications as a multi-phase data fusion theory have been empirically validated through a series of scenario-based Cyber SA experiments for detecting, tracking, and predicting XAPTs.
Background Schizophrenia spectrum disorders (SSDs) are presumed to be associated with retinal thinning. However, evidence is lacking as to whether these retinal alterations reflect a disease-specific process or are rather a consequence of comorbid diseases or concomitant microvascular impairment. Methods The study included 126 eyes of 65 patients with SSDs and 143 eyes of 72 healthy controls. We examined macula and optic disc measures by optical coherence tomography (OCT) and OCT angiography (OCT-A). Additive mixed models were used to assess the impact of SSDs on retinal thickness and perfusion and to explore the association of retinal and clinical disease-related parameters by controlling for several ocular and systemic covariates (age, sex, spherical equivalent, intraocular pressure, body mass index, diabetes, hypertension, smoking status, and OCT signal strength). Results OCT revealed significantly lower parafoveal macular, macular ganglion cell–inner plexiform layer (GCIPL), and macular retinal nerve fiber layer (RNFL) thickness and thinner mean and superior peripapillary RNFL in SSDs. In contrast, the applied OCT-A investigations, which included macular and peripapillary perfusion density, macular vessel density, and size of the foveal avascular zone, did not reveal any significant between-group differences. Finally, a longer duration of illness and higher chlorpromazine equivalent doses were associated with lower parafoveal macular and macular RNFL thickness. Conclusions This study strengthens the evidence for disease-related retinal thinning in SSDs.
The objective of this paper is to introduce CyCLOPS, a novel strategic research infrastructure unit, and present its current progress of implementation, and integration in the National geodetic, geophysical and geotechnical infrastructure of the government-controlled areas of the Republic of Cyprus. CyCLOPS is co-funded by the European Regional Development Fund and the Republic of Cyprus through the Research and Innovation Foundation under the grant agreement RIF/INFRASTRUCTURES/1216/0050. CyCLOPS is developed via the collaboration of the Cyprus University of Technology (CUT) and the German Aerospace Center (DLR), and supported by the Cyprus Geological Survey Department and the Department of Lands and Surveys. The main objective of CyCLOPS is to establish an integrated infrastructure for space-based monitoring of geohazards using the most prominent earth observation technologies (EO), such as GNSS and InSAR. Furthermore, the infrastructure will densify and form the backbone for the definition of the next generation national datum of the Republic of Cyprus. Eleven Tier-1/2 state-of-the-art GNSS CORS, precise weather stations, tiltmeters and specifically designed InSAR triangular trihedral corner reflectors will be deployed, in a collocated fashion, at selected locations throughout the government-controlled areas of Cyprus. The collocated configuration will be established and installed to be compliant with the most stringent CORS monumentation specifications, support all current GNSS constellations and SAR missions. Finally, one of CyCLOPS’ fundamental aims is to actively contribute to the on-going efforts and growing demand for more precise positioning services and high-quality modern reference frames, in conformity with the recommendations of the UN-GGIM (and its Subcommittee of Geodesy) to establish and enhance national geodetic infrastructures to support the sustainable management of geospatial information on the changing Earth.
This is a diachronic corpus-based semantic analysis of the verb plēróō in Ancient Greek, from 6th c. BCE to the 2nd c. ce. Adopting the usage-based profile approach, it inquiries into the relation between formal features and themes of discourse, following the methodological consequences of two theoretical assumptions: first, that textual themes have a prototypical structure. Second, that formal features as a conceptual schematicity underlying the elaborated and situated level of discourse are immanent to these themes. Methodologically, it implements a Multiple Correspondence Analysis for each century, exploring the contribution of the formal and a fine-grained range of semantic features to the variation, as well as the strength of association between them. In order to test the plausibility of the immanence hypothesis, the analysis implements a Hierarchical Agglomerative Clustering for the totality of data over the eight-century period, comparing the results of the latter with the individual MCA analyses.
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