BACKGROUND: Professional burnout in university teachers is an urgent problem. Thus, researchers attempted to determine the dependence of teachers health on the peculiarities of their professional activities. Professional burnout of teachers is observed in all countries worldwide. The development of measures to prevent professional burnout is an important task that requires further study. AIM: This study aimed to scientifically justify measures for the prevention of emotional burnout syndrome in university teachers. MATERIALS AND METHODS: A total of 2,711 teachers from humanitarian and technical universities in Moscow were surveyed using analytical and socio-hygienic methods. Moreover, extracts from medical, informational, and statistical documents of teachers were analyzed. RESULTS: On average, one university teacher was found to have 45 symptoms characterizing emotional burnout. Two-thirds of the teachers were women, and female morbidity was higher. The high intensity of professional activities, long-lasting forced position, and dissatisfaction with job and remuneration were defined as the most pronounced reasons of psychological burnout. CONCLUSIONS: Medical and organizational measures are necessary to improve the health and emotional state of teachers.