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The semivolatile portion of cigarette smoke contains acidic, basic, and neutral compounds that are important to the flavour and in some cases the physiological effects of smoke. A rapid method that could be used routinely for the gas chromatographic analysis of this portion of smoke was developed. A 160 mm glass capillary column was used to resolve approximately 150 semivolatile smoke components. Gas chromatography - mass spectrometry was used to identify about 35 of these components. Twenty known semivolatile compounds with different functional groups and boiling points were used to determine the effects of various filters on their removal from smoke. Standard cellulose acetate filters, cellulose acetate filters with glycerin, cellulose acetate filters with PEG 600, and cellulose acetate filters with activated carbon were evaluated. The cellulose acetate filters with glycerin and PEG 600 were more selective for the removal of aromatic hydrocarbons than were the standard cellulose acetate filters. The cellulose acetate filters with activated carbon were more selective for the removaI of the low-boiling semivolatile compounds than were the other filters tested.

If the distribution of specific smoke components with respect to particle size were significantly different than the size distribution of particulate matter, a compound or group of compounds might be selectively removed by the selective filtration of a given particle size. Various techniques have been used to determine the particle size distribution of a few smoke components. Berner and Marek used a Goetz aerosol spectrometer to determine the size distribution of potassium in smoke; and Owen, Westcott and Woodman used a conifuge to examine the distribution of three smoke components. In the present work, a cascade impactor was used to separate smoke particles into four fractions of 0.25 to 1.0 µ in diameter based on the principle that particles in a moving airstream impact on a slide placed in their path, if their momentum is sufficient to overcome the drag exerted by the airstream. The particle size distribution of five organic compounds: indole, nicotine, diethyl phthalate, norphytene, and neophytadiene were determined. These size distributions were compared to the distribution of total particulate matter (TPM) and the following observations were made:1. All compounds were distributed in a pattern similar to that of TPM. Therefore, the selective filtration of a given compound by selective filtration of a given particle size is probably unfeasible.2. The concentrations of indole and nicotine were higher in the medium-size particles (0.5 to 0.75 µ) than in the small or large particles.3. It is known that cellulose acetate filters are more efficient for the filtration of small and large particles than they are for medium-size particles. Therefore, the high concentration of nicotine in the medium-size particles may contribute to the slightly higher filtration efficiency these filters have for the TPM than they have for nicotine.

Solvent extraction is combined with gas chromatography to produce an effective method of analysis for aluminum, gallium, and indium mixtures. The

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