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Summary: Endocarditis caused by Fusobacterium nucleatum is exceedingly rare. We report a case of E nucleatum right-sided endocarditis in a patient with no known intravenous drug abuse. A detailed computer and manual search of the literature using Med-Line and Index Medicus, respectively, revealed a total of five cases of endocarditis due to this species. The clinical characteristics and the patient's hospital course are summarized and reviewed.Key words: endocarditis, tricuspid valve, Fusobacterium nucleatum revealed a total of five previously reported cases of endocarditis in which this species has been identified as a single causative agent,3*4 or as part of a polymicrobial infect i~n .~+~ The total number of cases of endocarditis due to the genus Fusobacterium included 15 cases: 7 of these were E necrophor~m,~ 5 were E n~c l e a t u m ,~-~ and 3 were unidentified Fusobacterium species."* Our case brings the total number of cases of identified E nucleatum endocarditis to six. The clinical features and hospital course of our patient, as well as those documented for E nucleatum, are reviewed and summarized (Table I). Case Report IntroductionInfections due to anaerobic gram-negative nonsporeforming bacilli, including the genera Bacteroides and Fusobacterium, have been well documented.' However, endocarditis caused by these organisms remains relatively uncommon and is mostly due to Bacteroidesfragilis.* Endocarditis caused by the Fusobacterium genus is exceedingly rare. We report a case of right-sided endocarditis due to Fusobacterium nucleatum (previously known as E fisiform).