This study investigated the psychometric qualities and validity of a Dutch translation of the Inventory of Personality Organization (IPO-NL) in a heterogeneous sample of 371 psychiatric patients and a sample of 181 normal controls. Results show good internal consistency and test-retest reliability. Exploratory factor analyses did not replicate its proposed five-factor structure, but suggested a four-factor structure instead. The IPO-NL appeared to have good concurrent validity across populations, and good convergent validity in terms of associations with measures of psychological distress and personality pathology severity. Taken together, the IPO-NL appears to be a useful instrument for evaluating general personality pathology for clinical practice. Future studies may further articulate its proposed subscales.