A highly potent donor-acceptor biaryl thermally activated delayed fluorescence (TADF) dye is accessible by a concise two-step sequence employing two-fold Ullmann arylation and a sequentially Pd-catalyzed Masuda borylation-Suzuki arylation (MBSA). Photophysical investigations show efficient TADF at ambient temperature due to the sterical hindrance between the donor and acceptor moieties. The photoluminescence quantum yield amounts to Φ = 80% in toluene and 90% in PMMA arising from prompt and delayed fluorescence with decay times of 21 ns and 30 μs, respectively. From an Arrhenius plot, the energy gap Δ E(S - T) between the lowest excited singlet S and triplet T state was determined to be 980 cm (120 meV). A new procedure is proposed that allows us to estimate the intersystem crossing time to ∼10 ns.

Natural bisindole alkaloids such as Hyrtinadine A and Alocasin A, which are known to exhibit diverse bioactivities, provide promising chemical scaffolds for drug development. By optimizing the Masuda borylation–Suzuki coupling sequence, a library of various natural product-derived and non-natural (di)­azine-bridged bisindoles was created. While unsubstituted bisindoles were devoid of antibacterial activity, 5,5′-chloro derivatives were highly active against methicillin-resistant Staphylococcus aureus (MRSA) and further Gram-positive pathogens at minimal inhibitory concentrations ranging from 0.20 to 0.78 μM. These compounds showed strong bactericidal killing effects but only moderate cytotoxicity against human cell lines. Furthermore, the two front-runner compounds 4j and 4n exhibited potent in vivo efficacy against MRSA in a mouse wound infection model. Although structurally related bisindoles were reported to specifically target pyruvate kinase in MRSA, antibacterial activity of 4j and 4n is independent of pyruvate kinase. Rather, these compounds lead to bacterial membrane permeabilization and cellular efflux of low-molecular-weight molecules.

N-Protected 3-iodoindoles were reacted with (di)azine halides in a sequentially Pd-catalyzed one-pot fashion, i.e., by Masuda borylation–Suzuki coupling (MBSC) sequence. This methodology was successfully applied to the concise syntheses of marine indole alkaloids meridianin C, D, F, and G, as well as to the bisindole alkaloid scalaridine A, which were obtained in moderate to excellent yield.

Beim (+)-Carvomenthen (2) und beim (+)-Limonen ( I ) tritt der Sauerstoff ausschlieRlich an der Al-Doppelbindung ein, nach dem Schema der ,,indirekt substituierenden Addition in der Allylstellung", unter Bildung samtlicher nach diesem Prinzip zu erwartender Hydroperoxyde. Die an der Produktverteilung gezeigte Stereoselektivitat der photosensibilisierten 02-Ubertragung laBt sich nur rnit der bevorzugten Ablosung der quasi-axialen Allylwasserstoffatome bei der Hydroperoxydbildung erklaren. Das ausschlieRliche Auftreten der drei trans-Allylalkohole des (+)-A3-Carens findet seine Erklarung darin, daR sich der zur cis-Allylalkoholsynthese erforderliche Ubergangszustand, der sich aus Sensibilisator, Sauerstoff und Olefin bilden muR, infolge der sterischen Hinderung durch den Dimethylcyclopropanring nicht einstellen kann.

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