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ENIGN PROSTATIC HYPERPLASIA (BPH) affects nearly 3 out of 4 men by the age of 70 years. 1,2 Medical management of BPH is often preferred to surgical treatment because surgery increases the risk of impotence and incontinence. An effective and commonly prescribed medication for BPH is tamsulosin, 3 which accounted for more than $1 billion in sales in 2007. 4 Tamsulosin is believed to relieve symptoms of BPH by relaxing smooth muscle in the prostate and bladder neck through systemic blockade of ␣ 1aadrenergic receptors. Because these receptors are present in dilator smooth muscle of the iris, tamsulosin may also impede mydriasis during surgery and lead to intraoperative floppy iris syndrome (IFIS). 5-14 In turn, IFIS may increase the risk of complications during cataract surgery. This association has prompted warnings regarding the risk of See also p 2044 and Patient Page.

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