Background: Mortality in outborns with Neonatal sepsis result from interaction of maternal-fetal colonization, transplacental immunity and physical and cellular defense mechanisms of neonates. Objective: The objective of this study was to determine risk factors 0f mortality in outborn with neonatal sepsis. Materials and Methods: A 6-months prospective observational study was done at neonatal intensive care unit of Benha university hospital and Serselyan General Hospital. All outborn neonates with maternal and neonatal risk factors of sepsis were enrolled. Blood culture, sepsis screen and other needed investigations were performed. Results: The mortality rate among outborn with neonatal sepsis was 42%.The common presentations among outborns with neonatal sepsis were Hypothermia, convulsions, cyanosis and poor suckling. The ,significant risk factors of mortality include Malesex (p=0.021), gestational age (p=0.027), presence of convulsions(p=0.003), cyanosis(p=0.02), hypothermia(p=0.009), mottling(p=0.001),poor suckling(p=0.001),positive c-reactive protein(p=0.009), Anemia(p=0.011)..Maternal factors such as Premature rupture of membranes (p=0.047)and hypertension during pregnancy (p=0.001) and diabetes mellitus (p=0.017) were statistically significant associated with mortality in outborn neonatal sepsis. On multivariate logistic regression temperature on admission and distance during transport to hospital were the predictive factors of mortality in outborn neonatal sepsis. Conclusion:Long distance tranelled with neonates during transport to hospital and presentation with hypothermia at admission, were the independent risk factors of mortality in outborn neonatal sepsis.