The aim of this research is to find if the pharmacologic agent regadenoson, will provide more false positives and lower positive predictive value than a treadmill exercise when doing a myocardial perfusion stress test. Methods:The patients for this research were the first 34 patients that were stressed with a treadmill exercise and the first 34 patients that were stressed using regadenoson. These patients were selected from a local hospital cardiac catheterization lab between the years of 2013 to 2015 starting January 2015, and working backward. These patients had to have a positive myocardial perfusion study and to have a catheterization procedure within six months of the last MPI test. We measured the false positive rate and the positive predictive value for both a treadmill exercise and regadenoson, using the catheterization results as the reference standard. Results:The findings suggest that regadenoson provides a higher false positive rate and a lower positive predictive value than a treadmill exercise. Conclusion:A treadmill exercise should be more utilized whenever possible to prohibit unnecessary cardiac catheterization procedures.