Inhalation technique is main therapy of chronic obstructive pulmonary disease (COPD). Incorrect usage of inhaler devices might have a major influence on the clinical effectiveness of the delivered drug. This issue is poorly addressed in management guidelines. The present study was carried out with an objective to assess the inhalation techniques in hospitalized patients with COPD using Metered Dose Inhalers (MDI) and rotahaler. The study consists of all hospitalized patients diagnosed with COPD above 40 years who are using MDI and rotahaler. The study was an institution based prospective and descriptive study done for 8 weeks. The data of the study was analysed using SPSS 20.0 version and Microsoft Excel 2007. Of 100 patients with COPD (mean age 68 years), most of the patients were illiterate (75%) with smoking habit (36%) and smoking history (48%). 84% patients do not use their inhalers correctly, the most common errors being "not exhaling to residual volume" and "not holding breath for 5 seconds". While using MDI, apart from above mentioned errors, the other frequent errors were not continuing slow and deep inhalation, not shaking the inhaler and not inhaling slowly and pressing canister. While using rotahaler, the other common errors apart from afore mentioned errors were not inhaling powder forcefully and deeply and not exhaling away from mouth piece. From the present study it can be concluded that incorrect inhalation techniques is common among COPD patients. The success of COPD management is highly dependent on correct use of inhalers. Thus, trainings, verbal instruction and technique assessment and reassessment are considered necessary to make patients use their inhalers correctly.