E-Learning has been massively used in higher education, one of which is in Universitas Indonesia. The e-learning system in Universitas Indonesia is called Student Centered E-Learning Environment Universitas Indonesia (SCELE UI). This research determines the effect of usability on the intention to use SCELE UI in a sustainable way. The Expectation Confirmation Model (ECM) is used as a basis of the research model. Perceived Usability, Learnability, Presentation, Navigation and Error variables are added to the model. The Partial Least Square is used to analyze and test the model. Of the 12 proposed hypotheses, 10 hypotheses were accepted and 2 hypotheses were rejected. This research gives theoretical and practical contributions. On the theoretical side, this research successfully proposes and examines the integration of usability and ECM in the context of sustain e-learning usage intention. This research reveals the indirect effect of Perceived Usability on continued usage intention of the e-learning system. On the practical side, this research also provides insights for developers and universities that can help them to effectively foster the improvement of their system that can ensure sustained usage by their students.